![]() ![]() Cells are likely to die during this process. However, layer-by-layer printing still takes a long time many hours for a multi-cubic centimeter object. And by using various inks at the same time, different kinds of cells could be deposited and in doing so create tissues. New nozzles, nutritious inks and pre-made scaffolds make it easier for the cells to survive this process. With the development of bioinks, 3D extrusion bioprinting has become possible. But to achieve this, highly detailed and differentiated tissues will have to be made: even a cubic millimeter of organ tissue will need blood capillaries in it as well, so the bar is set very high for printers if we want to create functional tissue that we can implant on a clinically relevant scale. In principle, it should be possible to replace the plastic and print pieces of biologically functional tissue, with different kinds of cells present. This has become quite famous in the past 15 years or so, with even over-the-counter printers available for the home. The first association with 3D bioprinting is ‘classic’ 3D printing or extrusion printing with plastic filament. In this article, three recent innovations by UMC Utrecht are highlighted that will help to make bioprinting more clinically relevant. However, printing living tissues and cells is extremely complicated, and many hurdles need to be overcome to be able to get there. It's a promising technique that hopefully, one day, can solve the organ donor shortage by growing organs from patients' own cells. view moreĬredit: The Levato Lab, UMC Utrecht Taking biofabrication to the next level: innovations in volumetric bioprinting UMC Utrecht researchers propose solutions for bioprinting living tissueīioprinting is the printing of living cells and tissues. Image: Embedded printing of cells in a granular gel.
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